Registration of a 3D mouse brain atlas with brain microstructure data

摘要

The brain tissue scanner http://research.cs.tamu.edu/bnl/ is being used to explore the topology and geometry of mouse brain architecture at two levels: its gross anatomy and its microstructure. Aligned volume data set acquisition using this instrument is described. A 3D atlas of mouse brain partitions the gross anatomical structures of brain by a solid model. When registered with the microstructure data, the model serves to organize and index the microstructure data. Volume element partitioning of the mouse brain data can provide a common coordinate framework for visualization and morphological modeling of neurons and can serve as containers to grow synthetic neurons.