Noninvasive fluorescence diagnostics in radiotherapy of mucosal oral tumors

摘要

The efficiency of noninvasive laser fluorescent diagnostics for the real clinical practice is now widely discussed in special publications. One of the most perspective application area of this diagnostic technique is the oncology. For that the overwhelming majority of the research is concentrated now in the problem of the differential diagnostics of the "normal-tumor" case for different localizations and clinical forms of the young tumors. Meanwhile, the fluorescent diagnostics can has high possibilities also as a monitoring of the efficiency for different methods of tumors treatment, the radiotherapy for instance. In this report the examples of the use of laser noninvasive fluorescent diagnostics in a real clinical practice of the Radiological Department of MONIKI are presented. There was under our investigation the group of around 100 patients with different oral mucosal tumors, for whom a course of a radiotherapy treatment was purposed and for whom the research background fluorescent noninvasive monitoring was applied during the course of the care. In the report the efficiency of such laser fluorescent monitoring is discussed. It is shown that there were the strong differences in fluorescent spectra for both different forms of mucosal tumor and for the same one. In the number of clinical cases there were not marked any special fluorescent signal for a mucosal strong tumor before a treatment. During the radiotherapy treatment the different responses in fluorescent spectra were observed as a reaction of tissues after the single γ-ray exposure and daily one as well. All this presented results allow us to propose a non-quite correct existed explanation of the nature of the biotissues fluorescent phenomenon in meaning of the diagnostics of soft tissue cancer cases.