Stability of PA/PI Mixed Liposomes against Aggregation

摘要

Liposome aggregation induced by Mg~(2+) ion was kinetically investigated for phosphatidic acid (PA)/phosphatidylinositol (PI) mixed system. Initial velocity of the aggregation was suppressed above the gel-to-liquid-crystalline phase transition temperature of PA/PI mixed bilayers. Moreover, PA/PI liposomes aggregated more slowly than the acidic phospholipid liposomes; the aggregation for the PI liposomes was irreversible with respect to salt concentration. These results suggest that a repulsive hydration force acts between the liposomes containing PI. However, the repulsive effect is not so strong as to suppress the irreversible aggregation.