Supramolecular chemistry, the chemistry of the non-covalent bond, has been used to design bottom up nanoarchitectures in a variety of applications. Its use in a biomimetic setting with small molecular weight monomers would generate a new class of biomaterial which stands to benefit from highly repeatable order and nano-scale control. A new scaffold biomaterial that can surface assemble on a hydrophobic surface and allow nano-scale positioning of residues would improve the repeatability of the surface residues and the biocompatibility of the surface. We have designed a scaffold system and studied several parameters, based on molecular design, that can control the characteristics of the resulting assembly. If this approach is successful, the scaffold can be used to recreate epitope structures and/or construct highly repeatable arrays of biological residues on a surface.
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