A Combinatorial Strategy for the Synthesis of Various Amino Acid Derivatives of C_(60) and C_(70)

摘要

An original strategy was developed for the synthesis of numerous novel amino acid derivatives of C_(60).This strategy is also applicable for the C_(70) fullerene.Using the extra functionality (-COOH,-OH or -NH_2) of the following polyfunctional amino acids Ser,Thr,Asp,Glu,Lys,Orn and hydroxy-Pro,novel compounds were generated by performing the "linking" chemistry electively on the free functional group,while the other groups were suitably protected.The functionalization reactions employed were Bingel cycloaddition and azide [3+2] dipolar addition.Our approach was driven by the necessity of developing water-soluble derivatives of C_(60) for pharmacological studies.