Meiotic exchange between homologous chromosomes takes place after the formation of a bundle of four chromatids. Crossovers are precise breakage-and-reunion events. Random strand involvements (no chromatid interference) and random distribution of crossovers (no chiasma interference) are usually assumed in analyzing genetic data. In this paper, we discuss a Markov model for chromatid interference. Closed form expression for the probability of any multilocus recombination/tetrad pattern is derived. Both chromatic interference and chiasma interference can be studied together using this model. In particular, we discuss chi-square models for chiasma interference.
展开▼
