Controlled release mcirospheres prepared by using an emulsion solvent-diffusion technique as a tool in design of new antidotes

摘要

The feasibility of producing controlled release indomethacin microspheres, with acrylic polymers Eudragit RS and RL, by employing two emulsion solvent-diffusion systems, is compared. Microspheres with various polymer/drug ration and polymer combinations (Eudragit RS/RL ratios) were prepared. The physical properties, loading efficiency and dissolution behaviour depended on the emulsion solvent-diffusion technique, polymer/drug ratio and polymer combination. The drug release is described on the basis of two bi-exponential, first-order models.