Engineering of Lipid-Based Nanoparticles with Accessible Nickel for Binding to His-tag Proteins and Antigens

摘要

Chemical tools are highly in demand for selective and efficient modification of cancer therapeutics and nanocarriers to enhance their ability to achieve improved drug delivery and efficacy. One of the major requirements for a successful cancer therapy is the ability to selectively annihilate cancer cells without harming normal cells and tissue. To achieve this ultimate goal, numerous studies have investigated various ways to selectively deliver chemotherapeutics to cancer cells. For the past two decades, researchers have explored the use of macromolecular scaffolds and nanocarriers to conjugate a number of potent cancer therapeutics. This strategy allows for enhancement of drug solubility in water, a major limitation of most cancer therapeutics, and the ability to achieve enhanced accumulation of the drug within the tumor tissue via the enhanced permeability and retention (EPR) effect.