Smart Polymeric Micelles from Block Copolymers for Gene and Drug Delivery

摘要

Polymeric micelle, the self-assembly of block copolymers with core-shell architecture, is a promising nanocarrier for drug and gene delivery. There are several relevant properties in polymeric micelle as nanocarrier systems, such as longevity in blood circulation, tissuepenetrating ability, spatial and temporal controlled drug release, and reduced inherent toxicity of cytotoxic reagents. Also, engineering of the block copolymer structure allows the preparation of polymeric micelles with integrated smart functions, such as targetability as well as stimulisensitivity. This presentation overviews the recent achievements as well as the future perspectives of polymeric micelles as smart nanocarriers for drug and nucleic acid delivery.