Urethane-Coupled Poly(ethylene glycol) Polymers Containing Hydrophobia End Groups NMR Characterization as a Step Toward Determining Aggregation Numbers in Aqueous Solutions

摘要

Urethane-coupled poly(ethylene glycol) polymers containing hydrophobic end groups are aqueous systems with remarkable rheological properties. Many of these polymers have been syn-thesized by using isophorone diisocyanate (IPD1) to couple seg-ments of poly(ethylene glycol) with hydrophobic aliphatic alkyl chains (R) through urethane linkages (IPDU). This chap-ter discusses the importance of chemical characterization of these polymers for mechanistic experiments and develops a 1H NMR method for this purpose. Two model compounds, reaction products oflPDI with methanol and 1-hexadecanol, are synthe-sized and used to understand the 2Jf NMR spectroscopy of these urethanes.