Role of plaque morphology in altering the flow characteristics in diseased coronary artery

摘要

Patient specific simulations of a single patient based on an accurate representation of the plaque in a diseased coronary artery with 35% stenosis are performed to understand the effect of inlet forcing frequency and amplitude on the wall shear stress (WSS). Numerical simulations are performed with unsteady flow conditions in a laminar regime. The results have revealed that at low amplitudes, WSS is insensitive to forcing frequency and is it in phase with Q. The maximum WSS is observed at the proximal region of the stenosis, and WSS has highest negative values at the peak location of the stenosis. For higher pulsatile amplitude (a > 1.0), WSS exhibits a strong sensitivity with forcing frequencies. At higher forcing frequency the WSS exhibits nonlinear response to the inlet forcing frequency. Furthermore, significant differences in the mean velocity profile are observed during maximum and minimum volumetric flow rates.