Component, Mobility and Specific Surface Area of Urinary Crystallites with Different Sizes in Urine of Healthy Human and Lithogenic Patients

摘要

The property difference of urine crystallites with different sizes in the urines of calcium oxalate (CaOx) calculi patients and healthy controls was comparatively investigated. Nanoparticle size analyzer was used to study the mobility of urine crystallites. Fast Fourier transformation (FFT) and and energy dispersive X-ray spectroscopy (EDS) was performed to detect the components of urinary crystallites. The specific surface area (S_g) of nanoscale urinary crystallites is greater than that of micron-grade urinary crystals. The mobility of the controls was more negative than that of the calculi patients. The effect of particle size on mobility was greater than that of the charges on surface of the particles. The amount of small-sized urine crystallites in the healthy subjects was significantly higher than that of the patients. However, the number of large micron-scale crystals in the controls was reduced remarkably. These results showed that the formation of CaOx calculi was closely related to the presence of UA and calcium phosphate crystallites in urine. The urinary system of calculi patients is unstable and very susceptible to urine crystallite aggregation.