Fast and Accurate Simulation of Simulated Moving Bed Chromatographic Processes with Linear Adsorption Isotherms

摘要

In this paper,we propose a new fast and accurate simulation method for highly efficient chromatographic columns with linear adsorption isotherms.The method is based on an analytical solution of the underlying partial differential equations using the method of characteristics,which describes the propagation of selected concentration values.The method is exact.The discretization of the concentrations is only used for the representation of the solution and the evaluation of the coupling conditions between the different columns.Application is demonstrated for binary 4-zone and ternary 8-zone SMB processes with center-cut separation.It is shown,that the computational effort can be reduced by more than factor 100 compared to the popular discrete cell model.