Surface-Enhanced Spatially Offset Raman spectroscopy (SESORS) for Subsurface Detection of Nanostar Probes

摘要

Early detection of molecular targets can greatly impact the clinical diagnosis and outcome of manydiseases such as cancer. Methods utilizing optical detection systems and Surface-Enhanced RamanScattering (SERS)-labeled nanoparticles provide a way of selectively targeting and obtaining signalsunique to the target diseases as well as in-vivo applications for biomass and biofuel research with plants.However, these modalities are often limited to surface level detection due to attenuation from layers ofhighly scattering and absorbing tissue. In this work, we utilize surface-enhanced spatially offset Ramanspectroscopy (SESORS) to probe through thick tissue to overcome this limitation. This modalitycombines high SERS signals generated by nanoparticles with a depth resolved detection technique calledspatially offset Raman spectroscopy (SORS). We show the detection and recovery of SERS signal inlayered systems comprising of optically mimicking gel as well as bone material.