An in-silico Construction of Plausible trans- and cis-Elements of Non-housekeeping Genes

摘要

Regulation through transcription factors is an important attribute to the complexity of an organism. Determining the transcription factors that regulate a gene in different cell types will help lay the foundation for building gene regulatory networks to understand their complexity. More importantly, it may lead to possible treatment of complex diseases, such as cancer, through transcriptional control. Here we present an exploratory analysis of expression data to better understand relationships among genes and transcription factors and identify possible genomic binding sites where physical interactions may occur and perhaps be validated.