CORRELATION BETWEEN FOAM EXTRUSION PROCESS PARAMETERS, MECHANICAL PROPERTIES AND PHARMACEUTICAL DOWNSTREAM PROCESSING

摘要

Over the last decade, pharmaceutical industry and academia have being exploring foam extrusion to enable oral drug products. Foaming provides a new dimension to extrusion operations in the pharmaceutical industry, by facilitating the manufacturing processes and enhancing drug release rates. For this study, foams of hydroxypropyl methylcellulose acetate succinate with different morphology were produced through foam extrusion. Correlations between variables expected to directly influence foam architecture (die size, gas type, gas concentration) and performance properties of the product (mechanical properties, foam densities, and milling behavior) were established.