The effects of polymer carrier, hot melt extrusion process and downstream processing parameters on the moisture sorption properties of amorphous solid dispersions

Feng Xin; Vo Anh; Patil Hemlata; Tiwari Roshan V.; Alshetaili Abdullah S.; Pimparade Manjeet B.; Repka Michael A.

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The effects of polymer carrier, hot melt extrusion process and downstream processing parameters on the moisture sorption properties of amorphous solid dispersions

机译：聚合物载体，热熔挤出工艺和下游工艺参数对非晶态固体分散体吸湿性能的影响

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Objective The aim of this study was to evaluate the effect of polymer carrier, hot melt extrusion and downstream processing parameters on the water uptake properties of amorphous solid dispersions.

机译：目的本研究的目的是评估聚合物载体，热熔挤出和下游加工参数对非晶态固体分散体吸水特性的影响。

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《Journal of Pharmacy and Pharmacology》 |2016年第5期|共13页
作者
Feng Xin; Vo Anh; Patil Hemlata; Tiwari Roshan V.; Alshetaili Abdullah S.; Pimparade Manjeet B.; Repka Michael A.;
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正文语种 eng
中图分类药理学;
关键词
amorphous; hot melt extrusion; moisture; polymer carrier; solid dispersion;

机译：非晶态;热熔挤出;水分;聚合物载体;固体分散体;

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1. The effects of polymer carrier, hot melt extrusion process and downstream processing parameters on the moisture sorption properties of amorphous solid dispersions [J] . Feng Xin, Vo Anh, Patil Hemlata, Journal of Pharmacy and Pharmacology . 2016,第5期

机译：聚合物载体，热熔挤出工艺和下游工艺参数对非晶态固体分散体吸湿性能的影响
2. Formulation performance and processability window for manufacturing a dual-polymer amorphous solid dispersion via hot-melt extrusion and strand pelletization [J] . Hormann T. R., Jaeger N., Funke A., International Journal of Pharmaceutics . 2018,第1a2期

机译：通过热熔挤出和链造粒制造双聚合物无定形固体分散体的配方性能和可加工性窗口
3. Hot melt extrusion (HME) for amorphous solid dispersions: Predictive tools for processing and impact of drug-polymer interactions on supersaturation [J] . SarodeA.L., SandhuH., ShahN., European journal of pharmaceutical sciences . 2013,第3期

机译：用于无定形固体分散体的热熔挤出（HME）：预测工具，用于处理和影响药物-聚合物相互作用对过饱和度的影响
4. Downstream Processing of a Ternary Amorphous Solid Dispersion: the Impacts of Spray Drying and Hot Melt Extrusion on Powder Flow, Compression and Dissolution [C] . Mark T. Davis, Catherine B. Potter, Gavin M. Walker AIChE Annual Meeting . 2018

机译：三元无定形固体分散的下游加工：喷雾干燥和热熔挤出对粉末流动，压缩和溶解的影响
5. Effects of Temperature and Moisture on Melt Processed Amorphous Solid Dispersions [D] . Tekanil, Thangthip. 2020

机译：温度和水分对熔融加工无定形固体分散体的影响
6. The Effects of Polymer Carrier Hot Melt Extrusion Process and Downstream Processing Parameters on the Moisture Sorption Properties of Amorphous Solid Dispersions [O] . Xin Feng, Anh Vo, Hemlata Patil, -1

机译：聚合物载体热熔挤出工艺和下游工艺参数对非晶态固体分散体水分吸附特性的影响
7. Optimising drug solubilisation in amorphous polymer dispersions: rational selection of hot-melt extrusion processing parameters [O] . Li, Shu, Tian, Yiwei, Jones, David S., 2016

机译：优化无定形聚合物分散体中的药物溶解度：合理选择热熔挤出加工参数
8. Allegations of Health Effects Reported to have been Experienced by some Workers and Office Staff during Batch Processing (Involving Polymer Melt Extrusion, Compounding, Devolitizing and/or Packaging) of certain Polymer Mixtures with Multi-component Mixtur [R] . 2011

机译：一些工人和办公室工作人员在批量处理（涉及聚合物熔体挤出，复合，脱挥发和/或包装）某些聚合物混合物与多组分混合物的过程中经历过健康影响的指控

The effects of polymer carrier, hot melt extrusion process and downstream processing parameters on the moisture sorption properties of amorphous solid dispersions

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