BRIEF COMMUNICATION: Genome wide DNA methylation patterns and transcription analysis in sheep muscle

摘要

The Carwell phenotype is a desirable inherited muscular hypertrophy of the Longissimus dorsi muscle in Poll Dorset sheep that does not have any detrimental effect on eating quality, fat deposition or detectable meat tenderness. The Carwell haplotype has been localized to a 350kb region on the distal end of OAR 18 near the Callipyge locus (Nicoll et al. 1998) containing three known genes. However, in spite of considerable effort in sequencing and resequencing, the causative mutation has not been identified. Although unsuccessful in identifying the causative mutation, these studies have revealed that the Carwell phenotype displays an imprinted inheritance pattern, with increased muscling associated with inheritance from the sire but not the dam.