NEW LOW-MOLECULAR CONJUGATES OF ANTITUMOR DRUGS WITH DERIVATIVES N-ACETYL-D-GALACTOSAMINE

摘要

Hepatocellular carcinoma is the most common liver tumor, the result of malignant degeneration of hepatocytes. In terms of the number of deaths, hepatocellular carcinoma ranks 2nd in the world among all malignant tumors according to the World Health Organization [1]. Existing drugs for nowadays have several disadvantages, such as: 1) low selectivity 2) a wide range of side effects 3) low efficiency. Therefore, there is an urgent need to find new highly effective antitumor agents for the treatment of liver diseases. The using of targeted delivery strategy would help to avoid these shortcomings.