STUDIES TOWARD THE SYNTHESIS OF BACTEROIDES FRAGILIS a-GALACTOSYLCERAMIDE (a-GalCer_(Bf))

摘要

Invariant Natural Killer T (iNKT) cells contribute to the innate immune response. Through T-cell receptors (TCR) expressed on the surface, iNKT cells recognize glycolipid antigens when presented by the antigen-presenting molecule CD1d on antigen presenting cells. The best-known lipid antigen for iNKT cells is the a-galactosylceramide KRN7000, a purely synthetic molecule, which can mediate a variety of pro-inflammatory and immuno-regulatory functions [1].