Thioglycosides (S-glycosides), in which a sulfur atom has replaced the glycosidic oxygen atom of carbohydrates, are tolerated by most biological systems. Their major advantages rely on the fact that they adopt similar conformations than the corresponding O-glycosides and especially that they prove to be less sensitive to acid/base or enzyme-mediated hydrolysis [1,2]. So far, few examples of natural S-glycosides were reported in the literature. Until recently, plant glucosinoiates were the only group of S-glycosides that were characterized in Nature. These compounds are found in brassicae and are involved in the plant protective strategy, called "mustard oil bomb, that occurs after their hydrolysis and subsequent degradation in toxic sulfur-containing compounds (thiocyanates, isothiocyanates, ...).
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