ANTI ALDOL REACTIONS BETWEEN AN L-ERYTHRULOSE DERIVATIVE AND α-CHIRAL ALDEHYDES

摘要

Since about ten years, we have been investigating the outcome of aldol reactions of boron enolates of protected L-erythrulose derivatives as well as their application to the synthesis of complex natural products. One example of such L-erythrulose derivatives is the α-acyloxy ketone 1. With this ketone, dicyclohexylboron chloride as the enolization reagent generates an E enolate which reacts with achiral aldehydes RCHO to stereoselectively form anti aldols 2.