PREPARATION OF POLYSACCHARIDE SUPRAMOLECULAR HYDROGELS THROUGH FORMATION OF INCLUSION COMPLEX OF AMYLOSE

摘要

Amylose, a natural linear polysaccharide with helical conformation linked through α-(1->4)-glycosidic linkages, is a well-known host compound that forms inclusion complexes with various lower molecular weight compounds, mainly by hydrophobic interactions between the guest molecules and the cavity of amylose. However, little has been reported regarding the formation of inclusion complexes between amylose and polymers. So far, we have developed a new method termed as "vine-twining polymerization" for the preparation of the amylose-polymer inclusion complexes, which was achieved by the phosphorylase-catalyzed enzymatic polymerization field in the presence of the hydrophobic guest polymers [1]. In addition, we prepared a new type of hydrogel by this polymerization manner, in which the cross-linking points in the produced hydrogel were composed of the inclusion complexes of amylose with hydrophobic graft-chains of a poly(acrylic acid sodium salt-graft-δ-valerolactone) [2]. Furthermore, the enzymatic disruption and reproduction of the hydrogels were achieved by combination of the amylase-catalyzed hydrolysis of amylose and the formation of amylose by the phosphorylase-catalyzed polymerization.