Overcoming chemoresistance using tumor mitochondria-targeted photodynamic therapy

摘要

Chemoresistance is a significant challenge in the treatment of patients with ovarian cancer. An important mechanism in resistance to cisplatin is increased drug efflux from tumor cells, potentially mediated by ATP-dependent factors such as the ATPases, ATP7A/ATP7B, and the ATP binding cassette (ABC) family member, MRP2. Therefore, a promising strategy to overcome chemoresistance is targeted inhibition of ATP production in tumor cells. In this work, we developed a mitochondria-targeted photodynamic therapy (PDT) approach in ovarian tumors to overcome chemoresistance.