Hierarchical Micro/Nanostructures of Natural Polymer for Release Process

摘要

In this paper the modeling of drug release process from hierarchical dispersed systems such as nano and microparticles prepared by thermal cross-linking of multiple emulsions is described. The presented model considers the diffusion of a drug through spherical eroding natural polymer matrix and diffusion-convection of the drug in the surrounding medium. Simulated release profiles were compared with experimental data of the drug release from microspheres of various structures. The differences in microspheres structure resulted from changes in mixing intensity of the external surrounding. The simulations of release profiles confirmed the importance of the internal structure of microspheres as well as an intensity of external mixing in the modeling of the controlled release process. The presented model allowed the mass of drug released to be determined with satisfactory agreement with experimental data after optimization of parameters describing internal microspheres structure. The proposed model describing release process of a drug from microspheres can be applied for simulation of release profiles with phasic behavior (primary/lag and continuous release). The model simulations were extended to drug release from nanoparticles with satisfactory results.