Surface Decorated Fe_3O_4 Nanoparticles for Magnetic Hyperthermia

摘要

Magnetic nanoparticles have been widely investigated for their great potential in several biomedical applications such as magnetic hyperthermia, drug delivery and magnetic resonance imaging (MRI). We have developed a formulation in which the surface of Fe_3O_4 magnetic nanoparticles is decorated with succinic acid (SA) to provide enhanced colloidal stability in biological fluids while preserving their optimal magnetic properties. The successful surface decoration of particles with SA is evident from FTIR, TGA, DLS and zeta-potential measurements. XRD and TEM analysis revealed the formation of inverse spinel Fe_3O_4 nanoparticles of average size -10 nm. Our induction heating studies exhibited the excellent heating efficacy of these nanoparticles under applied AC magnetic field. The heating ability was found to be strongly dependent on the concentration of particles in magnetic suspension and applied AC magnetic field. Specifically, a novel water-dispersible surface decorated Fe_3O_4 nanoparticles formulation was developed for magnetic hyperthermia.