- Superparamagnetic gold nanoparticle cluster-protein nanoparticle hybrid for MRI and magnetic hyperthermia

摘要

The present invention relates to a supercritical gold nanoparticle cluster-protein nanoparticle fusion for magnetic resonance imaging and magnetic hyperthermia treatment. According to the present invention, it is possible to provide a super-magnetic gold nanoparticle cluster-protein nano particle having a target orientation uniformly bound to the surface of protein nanoparticles without any additional surface stabilization process or target orientation imparting process Whereby a fused particle can be produced. Thus, the supercritical gold nanoparticle cluster-protein nanoparticle fusions according to the present invention exhibit superior biocompatibility and superior target orientation as compared to conventional gold nanoparticles, The temperature increase in the alternating magnetic field and the functionality as T2-MRI contrast agent were confirmed. Accordingly, the super-magnetic gold nanoparticle cluster-protein nanoparticle fusions according to the present invention can be used as a core technology in self-heating therapy and magnetic resonance imaging.