FRACTIONATION OF MAGNETIC MICROSPHERES FOR MAGNETIC DRUG TARGETING USING DEAN FLOW COMBINED WITH A MAGNETIC OCTUPOLE ON A CHIP

摘要

We present a microfluidic-chip-based concept for continuous fractionation of magnetic microspheres (MMS) having a broad size distribution. Fractionation is achieved through a combination of shear-induced inertial lift forces that act on particles flowing through a curvilinear channel (i.e., Dean Flow) and magnetostatic forces produced by an octupolar arrangement of magnets mounted below the chip. The chip was designed, built, and.tested using different MMS mixtures. The novel device enables the complete recovery of MMS from highly diluted suspensions, the separation of MMS mixtures, and size dependent fractionation of MMS