A MICROFLUIDIC DEVICE TO MIMIC THE BONE MARROW MICROENVIRONMENT: REAL-TIME OBSERVATION OF THE LEUKEMIC CELL BEHAVIOR

摘要

We investigated the possibility of mimicking the bone marrow (BM) microenvironment using a microfluidic device. We succeeded in observing the differentiation into osteoclasts (OCs) and the migration of leukemic cells into the mimicked BM microenvironment. We confirmed that the BM microenvironment was mimicked in vitro successfully. These findings suggest that this attractive device can contribute to medical research.