LAB-ON-A-CHIP FOR THE MAGNETIC ISOLATION AND ANALYSIS OF CIRCULATING TUMOR CELLS

摘要

The isolation and analysis of circulating tumor cells is very challenging because of the low abundance of CTCs in the peripheral blood and the physiological and morphological similarity to other blood cells. We report a miniaturized system which comprises immuomagnetic CTC isolation, multiplex ligation-dependent probe amplification (MLPA) and electrochemical gene detection.