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THERMOREGULATION IN HUMANS: RESULTS FROM AN ANATOMICALLY-BASED, HIGH RESOLUTION VOXELIZED MODEL

机译:人类的热调节:基于解剖学的高分辨率的体蛋白化模型的结果

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The ability to predict local surface and internal temperatures in humans subjected to various environmental and direct thermal loads has applications which include assessment of human exposure to radio frequency radiation (RFR) from mobile phones [1], medical imaging technologies [2] and mild-temperature hyperthermia (MTH) treatment for some cancers [3]. Numerous analytical and computational tools have been developed for the purpose of predicting tissue temperature changes in humans subjected to various thermal environments. Most previous whole-body models have been compartment or lumped-element models which lack anatomical detail. Such models are not capable of evaluating effects of non-uniform heating or cooling loads, differences in body type, or effects associated with subject body positioning (standing, sitting, reclining). The objectives of this work are (1) demonstrate a new high-resolution (2.0 mm) voxel model which incorporates active and passive thermoregulation, and (2) validate the model by comparing results with results from a compartment model, and with published experimental measurements in humans exposed to warm and hot environments.
机译:预测经受各种环境和直接热负荷的人类的局部表面和内部温度具有包括从移动电话[1],医学成像技术[2]和轻度 - 医学成像技术[2]和轻度 - 将人类暴露于射频辐射(RFR)的射频辐射(RFR)的应用程序。一些癌症的温度热疗(MTH)治疗[3]。已经开发了许多分析和计算工具,用于预测经受各种热环境的人类的组织温度变化。最先前的全身模型一直是隔室或集成元素模型,缺乏解剖细节。这些模型不能评估不均匀的加热或冷却载荷,身体类型的差异的效果,或与主体身体定位(站立,坐着,斜倚)相关的效果。这项工作的目标是(1)证明了一种新的高分辨率(2.0mm)voxel模型,它包含主动和被动温度调节,并且(2)通过将结果与舱室模型的结果进行比较,并且具有公开的实验测量来验证模型在暴露于温暖和热的环境中。

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