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AIRWAY REOPENING: THE PULSATILE PROPAGATION OF A FINGER OF AIR THROUGH A FLUID-OCCLUDED CYLINDRICAL TUBE

机译:气道重新开发:通过流体闭塞圆柱形管的空气手指脉动传播

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We computationally investigate the unsteady pulsatile propagation of a finger of air through a liquid-filled rigid cylindrical tube. This study is relevant to acute respiratory distress syndrome (ARDS), which is characterized by pulmonary airway collapse and fluid occlusion. Subsequent airway reopening, driven by mechanical ventilation, may generate damaging mechanical stresses on the airway walls that can result in ventilator-induced lung injury (VILI). We hypothesize that unsteady flows accompanied by dynamic surfactant transport may reduce the incidence of VILI. Herein we investigate the flow-field under constant surface tension to develop a fundamental understanding of unsteady flows in this system, and to identify the parametric ranges over which transport may be optimized to minimize pulmonary atelectrauma.
机译:我们计算通过填充液体刚性圆柱形管的空气手指的不稳定脉动传播。该研究与急性呼吸窘迫综合征(ARDS)有关,其特征在于肺气道塌陷和流体闭塞。通过机械通气驱动的随后的气道重新开放可能会在气道壁上产生损坏的机械应力,这可能导致呼吸机诱导的肺损伤(Vili)。我们假设伴随动态表面活性剂转运的不稳定流量可能会降低维利的发生率。在此我们研究了恒定表面张力下的流场,以在该系统中对非稳定流的基本理解,并识别可以优化运输以最小化肺电脉的参数范围。

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