(00588)Comparative Effects of Salinomycin and Meso-2,3-Dimercaptosuccinic Acid (DMSA)on Lead-Induced Impairment of Reproductive Function in Male Mice

摘要

Lead (Pb)directly targets testicular spermatogenesis and also the sperms in the epididymis inducing reproductive toxicity. In our study we compare the effects of meso-2,3-dimercaptosuccinic acid (DMSA)and tetraethylammonium salt of salinomycinic acid (Sal)on testis morphology, sperm count, Pb content, endogenous levels of calcium, copper, zinc and iron in testis of mice, subjected to Pb intoxication. Both chelating agents considerably reduced Pb content in the testis compared to the toxic control. The administration of Sal ameliorated Pb-induced alterations in Cu homeostasis and significantly restored endogenous Ca and Zn concentrations levels unlike DMSA. Testicular morphology of Pb-intoxicated mice recovered to control after salinomycin treatment but sperm count remained 21% lower compared to the untreated mice. The results suggest the potential application of salinomycin as antidote for treatment of lead intoxications.