Antagonist design of gelatinase biosynthesis-activating pheromone of Enterococcus faecalisbased on reverse alanine scanning

摘要

Anovel rational antagonist design strategy, reverse alanine scanning, was performed to create potent quorum sensing antagonists of Enterococcus faecalis. As a result, a potential lead antagonist, [Ala~(5.9.11)]Z-GBAP (IC_(20) = 10 μM) was derived from a receptor-binding scaffold of GBAP.