Toxicokinetic models and their applications

摘要

In this paper toxicokinetics was examined. Chemical distribution, absorption and elimination in the living organism were investigated. The aim of this paper kinetic of toxic substance during exposure in a biological system was studied. Several toxicokinetic models using physiological and biochemical parameters were derived. Physiologically based toxicokinetic models and similar pharmacokinetic models were represented. Physiological changes during chronic exposure to a xenobiotic are introduced. This paper contributes toxicokinetics investigation with the aim to pediction the contamined biological system behavior.