Determination of Leukotriene B_(4) (LTB_(4)) in Human Plasma by UFLC-MS/MS - A Novel Approach to Evaluate LTB_(4) as a Pharmacodynamic (PD) Biomarker in Pharmaceutical Development

机译：通过UFLC-MS / MS的人血浆中白三烯B_（4）（LTB_（4）） - 一种评估LTB_（4）作为药物发育中药效（Pd）生物标志物的新方法

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摘要

A novel UFLC-MS/MS method was developed and validated for the determination of LTB_(4) in ex vivo stimulated human plasma. The method was sensitive, robust and reliable. The validated method has been successfully used to support a clinical study.

机译：开发了一种新型UFLC-MS / MS方法，并验证了在例如刺激的人血浆中的LTB_（4）的测定。该方法敏感，稳健可靠。已验证的方法已成功用于支持临床研究。

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《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2010年||共1页
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Mike-Qingtao Huang; Naidong Weng; Weisheng Lin; Futain Han; Hsiaoju Lin; Zhongping (John) Lin; Xiaohua Xue; Anne Fourie; Ann Welton; Kirk Bertelsen; Jan de Jong;
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中图分类 TB994.5-53;
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入库时间 2022-08-21 10:19:32

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Determination of Leukotriene B_(4) (LTB_(4)) in Human Plasma by UFLC-MS/MS - A Novel Approach to Evaluate LTB_(4) as a Pharmacodynamic (PD) Biomarker in Pharmaceutical Development

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