MATRIX ASSISTED LASER DESORPTION IONIZATION IMAGING MASS SPECTROMETRY REVEALS THE MOLECULAR COMPOSITION OF HUMAN HEALTHY AND OSTEOARTHRITIC SYNOVIAL MEMBRANE

摘要

Potential OA markers have been successfully identified and localized in human synovial membranes by MALDI-MSI. Osteoarthritis (OA) is a rheumatic pathology involving degradation of joint. Its cause is still not completely known and there is no cure. MALDI-MSI involves the visualization of the spatial distribution of proteins, peptides or drug candidate compounds within thin slices of tissue. It is a promising tool for putative biomarker characterization. We have identified and localized OA markers by MALDI-MSI.