A Practical Integrated Approach to the Rapid Identification of Pharmaceutical Related Substance Impurities Tedizolid Phosphate (TR-701)~1 as an Example

摘要

For structure assignment of related substance impurities: (use all of the data you have) (1) Interpretation of nominal mass LC-MS data provides MW; (2) Measured accurate mass aids the assignment of molecular formulae; (3) UV spectra show changes to or retention of the molecule's chromophore; (4) Chemical knowledge provides an orthogonal corroboration of an assignment.