The Interactome for Transgenic Fragment Models of Huntington's Disease during Aging

摘要

1. Expression of different HTT N-terminal cleavage products results in accelerated phenotypes in mouse models of HD. 2. the caspase-2 fragment D552 is significantly more toxic than other fragments of similar length and abundance. 3. CoIP/MS/MS experiments identify 83 putative HTT-interacting proteins (>1 peptide identified) these include known proteins associated with HD and new interacting proteins.