Quantitative MS-based Proteomic Analysis of Human Neuroblastoma Cells under Hypoxic Stress

摘要

1. 2-D separation techniques increased the population of identified peptides 2. Quantitative analysis indicates increased expression of up-regulated proteins regardless of the postulated suppression of global protein synthesis 3. A preferential increase in the synthesis of certain proteins associated with cellular adaptation to hypoxia has been observed 4. A phosphoproteome study would provide insight into the regulation of signaling pathways that are associated with cellular adaptation to hypoxia