Twenty-Fold Assay Sensitivity Improvement for LC-MS/MS Bioanalysis of Dapagliflozin in Human Plasma

摘要

1. Assay sensitivity improvement of 20-fold for Dapa and 4-fold for Dapa_Glu was achieved. 2. Excellent assay accuracy and precision, selectivity, and consistent extraction recovery were demonstrated. - One LC column can be used for multiple runs. 3. This assay's sensitivity enables upcoming pediatric study sample analysis and potentially the application of dried blood spot technology in this drug's development program.