Epitope mapping of an anti-PCSK9 monoclonal antibody

机译：抗PCSK9单克隆抗体的表位映射

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摘要

1. Epitope mapping of an anti-PCSK9 monoclonal antibody was performed using two orthogonal approaches: limited proteolysis and ELISA assay 2. 3D5 epitope is localized to a surface loop of the catalytic domain of PCSK9 containing R215 and R218.

机译：1.使用两个正交方法进行抗PCSK9单克隆抗体的表位映射：有限的蛋白水解和ELISA测定2. 3D5表位局部化为含有R215和R218的PCSK9的催化结构域的表面环。

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《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2012年||共1页
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Anita Izrael-Tomasevic; Michael T. Lipari; Wei Li; Monica Beltran; Tao Sai; Joyce Lai; Ganesh Kolumam; Wilson Phung; Daniel Kirchhofer; David Arnott;
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Epitope mapping of an anti-PCSK9 monoclonal antibody

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