isolated monoclonal antibody or immunologically active fragment thereof, isolated bispecific monoclonal antibody, pharmaceutical composition, method for treating a disease in a human subject in need thereof, fusion protein, cd47 gene encoded immunodominant epitope, and biological molecule

摘要

The present invention provides novel CD47 antibodies or immunologically active fragments thereof which have low immunogenicity in humans and cause low or no level of red blood cell depletion or haemagglutination, as well as pharmaceutical compositions containing such antibodies that can be used for treatment of mediated diseases. by cd47 or inhibition of phagocytosis or platelet aggregation.