Ultra Rapid Separation of Cocaine and Cocaine Adulterants by Differential Ion Mobility Spectrometry - Mass Spectrometry

摘要

DMS with an ion trap interface was used for the ultra-rapid analysis of trace-level cocaine from a 10,000 part adulterant matrix to one part analyte. The 304 ion was not observed with the DMS off at a 10,000 to 1 matrix:analyte. With the DMS on, the 304 ion was observed as the base peak within the scan window. The linear dynamic rage of the method was 10pg to 10ng. The limit of detection of cocaine spiked into a 50 (mu)g Adulterant matrix of was 5 pg/(mu)L Increasing the fill time of the trap resulted in an MS signal increase of two orders of magnitude (1.67E6 -> 1.75E8) with samples run in triplicate from 5 to 10,000ms 4 to 6V separations were observed between cocaine and the various adulterants when EtOAc was employed as a dopant. A 2.4 fold signal increase was observed in MSMS mode when the DMS was employed as a selective pre-filter prior to mass analysis.