Molecular Pathology Using Desorption Electrospray Ionization Imaging Mass Spectrometry From the Lipid Profiles of Human Bladder, Kidney and Prostate Cancers

摘要

68 Prostate tissue samples from 34 patients were imaged using DESI-MS (resolution 200(mu)m). Changes in the GP profiles do not provide clear diagnosis by DESI-MS. Cholesterol sulfate at high relative intensities in cancerous tissues and tissues containing PIN. In the prostate tissue samples; cancer/precancerous vs. normal is correctly predicted in 64 out of 68 tissue samples using cholesterol sulfate as the marker compound. Future studies to evaluate cholesterol sulfate as a marker compound in serum or urine.