Determination of a Human Plasma Phospholipid Signature of Metabolic Syndrome by Mass Spectrometry-Based Metabolomics

摘要

Differences in the plasma phospholipid profile have been observed between human metabolic syndrome patients and healthy controls using LCMS and multivariate analysis. A mass-directed approach to data analysis provides a higher degree of confidence for correct data extraction and allows for targeted analysis of specific molecular species across multiple sample groups. Ultra-high mass accuracy of FTMS and MS/MS enable the identification of differentiating compounds with a high degree of confidence.