The Use of a new automated Blood Analyzer for the Determination of Immunosuppressants in Whole Blood

摘要

The described Blood Analyzer set-up enables an automated sample preparation immediately followed by LC-MS/MS-analysis of the immunosuppressants in whole blood. In addition automated sample tracking and customized reporting are part of the workflow. A sophisticated sample preparation protocol significantly reduces matrix effects. The LC-MS/MS method has been found robust precise and reproducible. Time and cost saving benefits also have to be considered. In the future other compounds of interest in whole blood will be investigated using the described workflow.