Screening Phosphatidylcholine Injection Samples for Impurities by HPLC-UV-MS and GC/MS

机译：通过HPLC-UV-MS和GC / MS筛选杂质的磷脂酰胆碱注射样品

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These methods can be used to look for impurities due to PC degradation. (1) LC-UV-MS can be used to screen for fatty acids, including hydroperoxy and keto FAs. (2) LC-UV-MS can be used to screen for lysoPC, including oxidized lysoPCs. (3) APCI+ appears to be better than ESI+ for the detection of acylglycerols. (4) GC/MS can be used to screen for aldehyde impurities in PC samples.

机译：这些方法可用于寻找由于PC劣化引起的杂质。（1）LC-UV-MS可用于筛选脂肪酸，包括氢过氧化物和酮酮。（2）LC-UV-MS可用于筛选Lysopc，包括氧化溶血性。（3）APCI +似乎比ESI +用于检测酰基甘油。（4）GC / MS可用于在PC样品中筛选醛杂质。

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《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2009年||共1页
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Jamie D. Dunn; Jeffrey T. Woodruff; John C. Reepmeyer; Michael E. Hadwiger; Benjamin J. Westenberger; Samia M. Nasr;
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Screening Phosphatidylcholine Injection Samples for Impurities by HPLC-UV-MS and GC/MS

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