PDT and Aspirin cause proteasome malfunctioning in human-derived lung adenocarcinoma cells

摘要

In this paper we reported that PDT and Aspirin individually induce a fast "but not irreversible" stall of proteasome activity of human lung carcinoma cell A549 (p53+/+) and H1299 (p53-/-). We demonstrated that this arrest can be protracted by their combination. More important, this combination stimulates apoptosis in these cancer cells prospecting enhanced therapeutic efficacy.Photodynamic therapy (PDT) of cancer involves administration of a tumor-localizing photosensitizer agent that, upon light stimulation, mediates cell destruction via production of singlet oxygen.Although side-effects void, PDT has a narrow field of application being currently used to treat selected cancer forms.