INCREASED MONOCYTE CHEMOTACTIC PROTEIN-1 CONCENTRATIONS ARE ASSOCIATED WITH DECREASED DISEASE-FREE INTERVAL AND SURVIVAL TIME IN DOGS WITH LYMPHOMA

摘要

Increased numbers of myeloid derived suppressor cells (MDSC) are commonly found in cancer patients and MDSC have been associated with tumor progression. Monocyte chemotactic factor-1 (MCP-1) has been implicated as one factor involved in expanding thenumbers of MDSC. We hypothesized therefore that serum MCP-1 concentrations would be increased in dogs with lymphoma and that dogs with high MCP-1 concentrations would have higher monocyte counts and shorter survival times.